Atrial Fibrillation: From Bench to Bedside (Contemporary Cardiology)

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Jane Everett. Lise Gaboury-Diallo. Charles Doutrelepont. Benoit Doyon-Gosselin. Claire Jaubert. Nattel S. New ideas about atrial fibrillation 50 years on. Nature ; A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate.

Atrial Fibrillation: From Bench to Bedside (Contemporary Cardiology)

J Am Coll Cardiol ; 43 The temporal variability of dominant frequency and complex fractionated atrial electrograms constrains the validity of sequential mapping in human atrial fibrillation. Heart Rhythm ; 7 Centrifugal gradients of rate and organization in human atrial fibrillation. Pacing Clin Electrophysiol ; 32 Real-time dominant frequency mapping and ablation of dominant frequency sites in atrial fibrillation with left-to-right frequency gradients predicts long-term maintenance of sinus rhythm.

Heart Rhythm ; 6 Electrical stimulation to identify neural elements on the heart: their role in atrial fibrillation. J Interv Card Electrophysiol ; 13 Clinical mapping approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation. J Cardiovasc Electrophysiol ; 23 Panoramic electrophysiological mapping but not electrogram morphology identifies stable sources for human atrial fibrillation: stable atrial fibrillation rotors and focal sources relate poorly to fractionated electrograms.

Circ Arrhythm Electrophysiol ; 6 Direct or coincidental elimination of stable rotors or focal sources may explain successful atrial fibrillation ablation: on-treatment analysis of the CONFIRM trial Conventional ablation for AF with or without focal impulse and rotor modulation. J Am Coll Cardiol ; 62 Heart Rhythm ;LB abstract. Focal impulse and rotor modulation ablation of sustaining rotors abruptly terminates persistent atrial fibrillation to sinus rhythm with elimination on follow-up: a video case study.

Heart Rhythm ; 9 J Am Coll Cardiol ; 60 Initial independent outcomes from focal impulse and rotor modulation ablation for atrial fibrillation: multicenter FIRM registry. J Cardiovasc Electrophysiol ; 25 Lewis ST. Chicago: Chicago Medical Book Company, Circus movement in rabbit atrial muscle as a mechanism of tachycardia.

Circ Res ; 41 Sustained vortex-like waves in normal isolated ventricular muscle. Spatial and temporal organization during cardiac fibrillation.

Stationary and drifting spiral waves of excitation in isolated cardiac muscle. Mechanisms of cardiac fibrillation. Science ; Evidence for multiple mechanisms in human ventricular fibrillation. Circulation ; Epicardial ablation of rotors suppresses inducibility of acetylcholine-induced atrial fibrillation in left pulmonary vein-left atrium preparations in a beagle heart failure model. Pandit SV, Jalife J.

Rotors and the dynamics of cardiac fibrillation. Circ Res ; Cardiac fibrillation: from ion channels to rotors in the human heart. Heart Rhythm ; 5 Regional entrainment of atrial fibrillation studied by high-resolution mapping in open-chest dogs. Circulation ; 88 Rotor meandering contributes to irregularity in electrograms during atrial fibrillation.

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Jalife J. Cardiovasc Res ; 89 Berenfeld O, Pertsov AM.

From Bench to Bedside

Dynamics of intramural scroll waves in three-dimensional continuous myocardium with rotational anisotropy. J Theor Biol ; Heterogeneous atrial wall thickness and stretch promote scroll waves anchoring during atrial fibrillation. Cardiovasc Res ; 94 G-Protein beta 3 -subunit T allele is associated with enhanced human atrial inward rectifier potassium currents. Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability. Adenoviral expression of IKs contributes to wavebreak and fibrillatory conduction in neonatal rat ventricular cardiomyocyte monolayers.

A major role for HERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer. J Physiol ; Circ Res ; :e Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation. Intramural activation during early human ventricular fibrillation.

Circ Arrhythm Electrophysiol ; 4 New magnetic resonance imaging-based method for defining the extent of left atrial wall injury after the ablation of atrial fibrillation. J Am Coll Cardiol ; 52 Separating non-isthmus- from isthmus-dependent atrial flutter using wavefront variability. J Am Coll Cardiol ; 45 J Am Coll Cardiol ; 63 Evaluating fluctuations in human atrial fibrillatory cycle length using monophasic action potentials.

Pacing Clin Electrophysiol ; 29 Repolarization and activation restitution near human pulmonary veins and atrial fibrillation initiation: a mechanism for the initiation of atrial fibrillation by premature beats. Repolarization alternans reveals vulnerability to human atrial fibrillation. Atrial conduction slows immediately before the onset of human atrial fibrillation: a bi-atrial contact mapping study of transitions to atrial fibrillation. J Am Coll Cardiol ; 59 Mechanisms of human atrial fibrillation initiation: clinical and computational studies of repolarization restitution and activation latency.

Circ Arrhythm Electrophysiol ; 5 Theoretical considerations for mapping activation in human cardiac fibrillation. Chaos ; 23 Noncontact mapping of the left ventricle: insights from validation with transmural contact mapping. Pacing Clin Electrophysiol ; 27 Classifying fractionated electrograms in human atrial fibrillation using monophasic action potentials and activation mapping: evidence for localized drivers, rate acceleration, and nonlocal signal etiologies.

Computational mapping identifies localized mechanisms for ablation of atrial fibrillation. PLoS One ; 7 :e Demonstration of the proarrhythmic preconditioning of single premature extrastimuli by use of the magnitude, phase, and distribution of repolarization alternans. Acute termination of human atrial fibrillation by identification and catheter ablation of localized rotors and sources: first multicenter experience of focal impulse and rotor modulation FIRM ablation. Results of focal impulse and rotor modulation FIRM for atrial fibrillation are equivalent between patients treated in San Diego compared with sites new to FIRM ablation: an extended multi-center experience.

Dr Benjamin received his medical degree from Johns Hopkins University School of Medicine and has been in practice for more than 20 years. The global challenge of heart attacks and strokes — resolve to treat hypertension.


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Dr Fuster has made significant contributions throughout his professional career to the advancement of cardiology research, the prevention and treatment of cardiovascular disease, particularly coronary artery disease, atherosclerosis and thrombosis. Thomas F. Professor Thomas F. Prior to his current position he was Professor of Pharmacotherapy at the University of Basel, then Professor and vice-chairman of cardiology at the Inselspital of the University of Berne, Switzerland.

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